4-[4-氟-3-[(4-甲氧基哌啶-1-基)羰基]苄基]酞嗪-1(2H)-酮合成路线 （共 2 条）
反应条件
4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane T=20 - 23°C; Product distribution / selectivity;
参考文献
ASTRAZENECA AB
Patent: US2011/15393 A1, 2011 ;
Location in patent: Page/Page column 7 ;
反应条件
O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine in DMA T=20°C; 21 h; Product distribution / selectivity;
参考文献
MENEAR, Keith Allan; Javaid, Muhammad Hashim; Gomez, Sylvie; Hummersone, Marc Geoffrey; Lence, Carlos Fenandez; Martin, Niall Morrison Barr; Rudge, David Alan; Roberts, Craig Anthony; Blades, Kevin
Patent: US2009/192156 A1, 2009 ;
Location in patent: Page/Page column 66 ;
