2-氧代-4-乙氧基-1,2-二氢吡啶-3-甲酸乙酯合成路线 （共 3 条）
反应条件
1: With acetic acid
Reflux;
2: With sodium hydrogencarbonate in water
pH=~ 9 - 10;
参考文献
DECIPHERA PHARMACEUTICALS, LLC; FLYNN, Daniel, L.; KAUFMAN, Michael, D.
Patent: WO2011/139891 A1, 2011 ;
Location in patent: Page/Page column 59 ;
WO 2011/139891 A1
反应条件
1.1: acetic acid / 120 - 130 °C
2.1: 2 h / 70 °C
3.1: acetic acid / Reflux
3.2: pH ~ 9 - 10
View Scheme
参考文献
DECIPHERA PHARMACEUTICALS, LLC; FLYNN, Daniel, L.; KAUFMAN, Michael, D.
Patent: WO2011/139891 A1, 2011 ;
WO 2011/139891 A1
反应条件
1.1: 2 h / 70 °C
2.1: acetic acid / Reflux
2.2: pH ~ 9 - 10
View Scheme
参考文献
DECIPHERA PHARMACEUTICALS, LLC; FLYNN, Daniel, L.; KAUFMAN, Michael, D.
Patent: WO2011/139891 A1, 2011 ;
WO 2011/139891 A1
