1-异丙基-1,3-二氢-2-苯并呋喃合成路线 (共 3 条)
反应条件
1: 1-(Chloromethyl)-2-iodobenzene With iso-propylmagnesium bromide in tetrahydrofuran T=-10°C; Substitution; 1.5 h; 2: isobutyraldehyde in tetrahydrofuran T=-10°C; Grignard reaction; 1 h; 3: in tetrahydrofuran Cyclization; 12 h; Heating; Further stages.;
参考文献
Delacroix; Berillon; Cahiez; Knochel
Journal of Organic Chemistry, 2000 , vol. 65, # 23 p. 8108 - 8110
反应条件
1: 1,3-dihydro-isobenzofuran With n-butyllithium; 2-(dimethylamino)-ethanol in hexane T=-15°C; 0.333333 h; 2: 2-iodo-propane in tetrahydrofuran T=-78°C;
参考文献
Fort, Yves; Gros, Philippe; Rodriguez, Alain L
Tetrahedron Letters, 2002 , vol. 43, # 22 p. 4045 - 4048
反应条件
in N,N,N',N',N'',N''-hexamethylphosphoric triamide T=220°C; reaction of benzenedimethanol derivatives; Product distribution;
参考文献
Canonne,P.; Plamondon,J.; Akssira,M.
Tetrahedron, 1988 , vol. 44, p. 2903