3-(N-Boc-氨甲基)苯甲酸合成路线 （共 16 条）
反应条件
1: With water; lithium hydroxide hydrate in tetrahydrofuran T=25 - 50°C; 4 h; 2: With acetic acid in ethyl acetate
参考文献
ANTHEM BIOSCIENCES PRIVATE LIMITED
Patent: US2012/101099 A1, 2012 ;
Location in patent: Page/Page column 28-30 ;
反应条件
1: NH3 / Raney Ni / ethanol / 51714.8 Torr 2: aq. NaOH / dioxane View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 13 p. 2175 - 2179
反应条件
triethylamine in water Ambient temperature;
参考文献
Jackson, Sharon; DeGrado, William; Dwivedi, Anil; Parthasarathy, Anju; Higley, Anne; Krywko, James; Rockwell, Arlene; Markwalder, Jay; Wells, Greg; Wexler, Ruth; Mousa, Shaker; Harlow, Richard
Journal of the American Chemical Society, 1994 , vol. 116, # 8 p. 3220 - 3230
反应条件
palladium on carbon in ethanol
反应条件
palladium in methanol; ethanol
参考文献
US5231102 A1, ;
US 5231102 A
反应条件
di-tert-butyl dicarbonate; triethylamine in 1,4-dioxane; water
参考文献
Pfizer Inc.
Patent: US6358951 B1, 2002 ;
Location in patent: Example 1 ;
反应条件
1: N-bromosuccinmide / 2,2'-azo-bisisobutyronitrile / tetrachloromethane / 3 h / 25 °C / Reflux 2: thionyl chloride / 1 h / 25 °C / Reflux 3: N,N-dimethyl-formamide / 12 h / 85 °C 4: hydrazine hydrate / methanol / 4 h / 25 °C / Reflux 5: sodium hydrogencarbonate / ethyl acetate; water / 1.17 h / pH 8 6: water; lithium hydroxide hydrate / tetrahydrofuran / 4 h / 25 - 50 °C View Scheme
参考文献
WO2011/21209 A1, ;
WO 2011/021209 A1
参考文献
Zhang, Lin-hua; Ma, Philip
Tetrahedron Letters, 1994 , vol. 35, # 32 p. 5765 - 5768
反应条件
sodium hydroxide in 1,4-dioxane
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 13 p. 2175 - 2179
反应条件
1: thionyl chloride / 1 h / 25 °C / Reflux 2: N,N-dimethyl-formamide / 12 h / 85 °C 3: hydrazine hydrate / methanol / 4 h / 25 °C / Reflux 4: sodium hydrogencarbonate / ethyl acetate; water / 1.17 h / pH 8 5: water; lithium hydroxide hydrate / tetrahydrofuran / 4 h / 25 - 50 °C View Scheme
参考文献
WO2011/21209 A1, ;
WO 2011/021209 A1
