2,5-二氯-6-甲基-3-吡啶羧酸合成路线 （共 3 条）
反应条件
dichlorophenyl phosphine oxide T=135°C; 1.5 h;
参考文献
Cale Jr.; Gero; Walker; Lo; Welstead Jr.; Jaques; Johnson; Leonard; Nolan
Journal of Medicinal Chemistry, 1989 , vol. 32, # 9 p. 2178 - 2199
参考文献
A. H. Robins Company, Inc.
Patent: US4705853 A1, 1987 ;
反应条件
1: 49 percent / 1) aq. conc. NaOH, 2) aq. 5.25 percent NaOCl / 18 h / Ambient temperature 2: 31 percent / phenylphosphonic dichloride / 1.5 h / 135 °C View Scheme
参考文献
Cale Jr.; Gero; Walker; Lo; Welstead Jr.; Jaques; Johnson; Leonard; Nolan
Journal of Medicinal Chemistry, 1989 , vol. 32, # 9 p. 2178 - 2199
