4-(苄氧基)-2-氯苯甲醛合成路线 （共 5 条）
反应条件
1: benzyl alcohol With sodium hydride in N,N-dimethyl-formamide; oil
T=20°C; 0.5 h; Inert atmosphere;
2: 2-Chloro-4-fluoro-benzaldehyde in N,N-dimethyl-formamide
T=20°C; 18 h;
参考文献
Cho, Hoon; Wu, Ying; Choi, Cheol-Hee
Patent: US2011/269954 A1, 2011 ;
Location in patent: Page/Page column 30-31 ;
US 20110269954 A1
反应条件
caesium carbonate in N,N-dimethyl-formamide
T=20°C; 72 h; Product distribution / selectivity;
参考文献
TIBOTEC PHARMACEUTICALS LTD.
Patent: WO2008/99022 A1, 2008 ;
Location in patent: Page/Page column 37 ;
反应条件
tetra-(n-butyl)ammonium iodide; potassium carbonate in acetonitrile
T=20°C;
参考文献
SK HOLDINGS CO., LTD.; PARK, Cheol-Hyoung; MIN, Hye-Kyung; LIM, Mi-Jung; LEE, Ji-Won; CHUNG, Jin-Yong; RYU, Choon-Ho; YOON, Yeo-Jin; JI, Mi-Kyung; PARK, Joo-Young
Patent: WO2010/98600 A2, 2010 ;
Location in patent: Paragraph 188-189 ;
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran; toluene
T=0 - 20°C; Mitsunobu Displacement;
参考文献
Choi, Dubok; Piao, Yu Lan; Wu, Ying; Cho, Hoon
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 15 p. 4477 - 4484
反应条件
1: diisobutylaluminium hydride / tetrahydrofuran; hexane / 3 h / -78 - 20 °C
2: caesium carbonate / acetonitrile / 2 h / 20 °C
View Scheme
参考文献
LG LIFE SCIENCES LTD.; KIM, Young Kwan; KIM, Myoung Yeol; PARK, Sang Yun; PARK, Ok Ku; ARTEMOV, Vasily; LEE, Sang Dae; JOO, Hyun Woo; CHOI, Eun Sil
Patent: WO2014/69963 A1, 2014 ;
