(R)-2-(氨基甲基)吗啉-4-羧酸叔丁酯合成路线 （共 4 条）
反应条件
ethanolamine T=20°C; 16 h;
参考文献
ASTRAZENECA AB; CANTIN, Louis-David; MARTINO, John; TOMASZEWSKI, Miroslaw; YU, Xiao Hong
Patent: WO2012/158117 A1, 2012 ;
Location in patent: Page/Page column 21; 23 ;
WO 2012/158117 A1
反应条件
palladium 10 on activated carbon; ammonium formate in methanol T=20°C; 17 h; Inert atmosphere;
参考文献
Journal of Medicinal Chemistry, , vol. 52, # 15 p. 4810 - 4819
反应条件
1: triethylamine / dichloromethane / 1.5 h / 0 - 20 °C 2: N,N-dimethyl-formamide / 16 h / 110 - 115 °C 3: ethanolamine / 16 h / 20 °C View Scheme
参考文献
WO2011/62550 A1, ;
WO 2011/062550 A1
反应条件
1: N,N-dimethyl-formamide / 16 h / 110 - 115 °C 2: ethanolamine / 16 h / 20 °C View Scheme
参考文献
WO2011/62550 A1, ;
WO 2011/062550 A1
