2-硫氧代-2,3- 二氢噻吩并[2,3-d]嘧啶-4(1H)-酮合成路线 （共 4 条）
反应条件
1: in N,N-dimethyl-formamide T=150°C; 6 h; 2: With citric acid in water T=0°C; 0.5 h;
参考文献
Amgen Inc.
Patent: US2008/32988 A1, 2008 ;
Location in patent: Page/Page column 22 ;
US 20080032988 A1
反应条件
1: in N,N-dimethyl-formamide T=150°C; 6 h; 2: With citric acid in water T=0°C; 0.5 h;
参考文献
Chen, Jian Jeffrey; Dewdney, Nolan James; Stahl, Christoph Martin
Patent: US2003/207900 A1, 2003 ;
Location in patent: Page/Page column 18 ;
US 20030207900 A1
反应条件
1.1: acetone / 0.5 h / Reflux 1.2: 2 h / Reflux 2.1: potassium hydroxide / ethanol / 2 h / Reflux 2.2: 1 h / 20 °C View Scheme
参考文献
Song, Yang-Heon; Son, Hoon Young
Journal of Heterocyclic Chemistry, 2011 , vol. 48, # 3 p. 597 - 603
反应条件
sodium hydroxide T=5°C; Reflux;
参考文献
Song, Yang-Heon; Son, Hoon Young
Journal of Heterocyclic Chemistry, 2011 , vol. 48, # 3 p. 597 - 603
