2-氯-3-硝基-6-三氟甲基吡啶合成路线 (共 3 条)
反应条件
1: With fuming sulfuric acid; dihydrogen peroxide in water T=0 - 25°C; 20 h; 2: With ammonia in water
参考文献
SUNESIS PHARMACEUTICALS, INC.
Patent: WO2006/65703 A1, 2006 ;
Location in patent: Page/Page column 107 ;
WO 2006/065703 A1
反应条件
phosphorus pentachloride; sulfuric acid; nitric acid; trichlorophosphate 1.) 50 deg C, 18 h, 2.) 90 deg C, 18 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of Heterocyclic Chemistry, , vol. 33, # 2 p. 287 - 293
反应条件
ammonia in ethanol
T=20°C; 15 h;
参考文献
SUNESIS PHARMACEUTICALS, INC.
Patent: WO2006/65703 A1, 2006 ;
Location in patent: Page/Page column 107 ;
WO 2006/065703 A1