反应条件
Stage #1: <a href="#" onclick="return RXDsubstances(event, this, '106756', constants.ctx, '0')">4-iodopyrazole</a> <b>With</b> <a href="#" onclick="return RXDsubstances(event, this, '4122952', constants.ctx, '0')">sodium hydride</a> <b>in</b> <a href="#" onclick="return RXDsubstances(event, this, '20272801', constants.ctx, '0')">miheral oil</a>; <a href="#" onclick="return RXDsubstances(event, this, '605365', constants.ctx, '0')">N,N-dimethyl-formamide</a> <br />T=0°C; <br />Stage #2: <a href="#" onclick="return RXDsubstances(event, this, '128422', constants.ctx, '0')">4-oxanyl methanesulfonate</a> <b>in</b> <a href="#" onclick="return RXDsubstances(event, this, '605365', constants.ctx, '0')">N,N-dimethyl-formamide</a>; <a href="#" onclick="return RXDsubstances(event, this, '8190416', constants.ctx, '0')">mineral oil</a> <br />T=100°C; <br /> <br />
参考文献
VERTEX PHARMACEUTICALS INCORPORATED; LAUFFER, David; LI, Pan; MCGINTY, Kira; RONKIN, Steven; TANG, Qing; GRILLOT, Anne-Laure; WAAL, Nathan Patent: WO2010/48131 A1, 2010 ; Location in patent: Page/Page column 52-53 ;
