2-(2-羧基甲基苯氧基)-3,4-二甲基苯甲酸合成路线 （共 9 条）
反应条件
1: 2-(2-hydroxyphenyl)acetic acid With potassium tert-butylate in N,N-dimethyl-formamide T=80°C; 2: sodium 2-iodo-3,4-dimethyl-benzoate With copper(l) chloride in N,N-dimethyl-formamide T=85°C; 2 h;
参考文献
NOVARTIS AG
Patent: WO2009/156459 A1, 2009 ;
Location in patent: Page/Page column 6 ;
反应条件
tri[2-(2-methoxyethoxy)ethyl]amine; copper(l) chloride in dimethyl sulfoxide T=95°C; 12 h;
参考文献
Rewcastle, Gordon W.; Atwell, Graham J.; Zhuang, Li; Baguley, Bruce C.; Denny, William A.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 217 - 222
反应条件
tri[2-(2-methoxyethoxy)ethyl]amine; copper(l) chloride in N,N-dimethyl-formamide T=85°C; 4 h;
参考文献
Atwell, Graham J; Yang, Shangjin; Denny, William A
European Journal of Medicinal Chemistry, 2002 , vol. 37, # 10 p. 825 - 828
反应条件
palladium on activated charcoal; hydrogen
参考文献
Yang, Shangjin; Denny, William A.
Tetrahedron Letters, 2009 , vol. 50, # 27 p. 3945 - 3947
反应条件
1: 65 percent / KOH, KCl, 27percent H2O2 / 20 °C 2: 1.) concd. H2SO4, NaNO2, 2.) KI / 1.) water, 10 deg C, 2.) 100 deg C 3: 63 percent / tris<2-(2-methoxyethoxy)ethyl>amine (TDA-1), CuCl / dimethylsulfoxide / 12 h / 95 °C View Scheme
参考文献
Rewcastle, Gordon W.; Atwell, Graham J.; Zhuang, Li; Baguley, Bruce C.; Denny, William A.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 217 - 222
反应条件
1: 65 percent / CH3SO3H / 70 - 80 °C 2: 65 percent / KOH, KCl, 27percent H2O2 / 20 °C 3: 1.) concd. H2SO4, NaNO2, 2.) KI / 1.) water, 10 deg C, 2.) 100 deg C 4: 63 percent / tris<2-(2-methoxyethoxy)ethyl>amine (TDA-1), CuCl / dimethylsulfoxide / 12 h / 95 °C View Scheme
参考文献
Rewcastle, Gordon W.; Atwell, Graham J.; Zhuang, Li; Baguley, Bruce C.; Denny, William A.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 217 - 222
反应条件
1: 1.) concd. H2SO4, NaNO2, 2.) KI / 1.) water, 10 deg C, 2.) 100 deg C 2: 63 percent / tris<2-(2-methoxyethoxy)ethyl>amine (TDA-1), CuCl / dimethylsulfoxide / 12 h / 95 °C View Scheme
参考文献
Rewcastle, Gordon W.; Atwell, Graham J.; Zhuang, Li; Baguley, Bruce C.; Denny, William A.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 217 - 222
反应条件
1: Na2SO4, hydroxylamine sulfate, concd. HCl / H2O 2: 65 percent / CH3SO3H / 70 - 80 °C 3: 65 percent / KOH, KCl, 27percent H2O2 / 20 °C 4: 1.) concd. H2SO4, NaNO2, 2.) KI / 1.) water, 10 deg C, 2.) 100 deg C 5: 63 percent / tris<2-(2-methoxyethoxy)ethyl>amine (TDA-1), CuCl / dimethylsulfoxide / 12 h / 95 °C View Scheme
参考文献
Rewcastle, Gordon W.; Atwell, Graham J.; Zhuang, Li; Baguley, Bruce C.; Denny, William A.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 217 - 222
反应条件
sulfuric acid in water T=80°C; 0.166667 h;
参考文献
Yang, Shangjin; Denny, William A.
Tetrahedron Letters, 2009 , vol. 50, # 27 p. 3945 - 3947
