反应条件
1: SOCl2, DMF / 0.5 h / Heating
2: NaBH4 / bis-(2-methoxy-ethyl) ether / 0.5 h / 20 °C
3: 93 percent / PBr3 / benzene / 0.17 h / 20 °C
4: 100 percent / Bu4NBr / CH2Cl2; H2O / 1 h / 20 °C
5: 88 percent / aq. NaOH / ethanol / 15 h / Heating
6: H2 / Pd/C / ethanol
View Scheme
参考文献
Rewcastle, Gordon W.; Atwell, Graham J.; Baguley, Bruce C.; Calveley, Stephen B.; Denny, William A.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 4 p. 793 - 799
