hydrogen; palladium in methanol P=760 Torr; 2 h; Ambient temperature;

<b>Multi-step reaction with 4 steps<br /> </b>1: 89.8 percent / K₂CO₃ / acetone / 72 h / Ambient temperature<br />2: 98.2 percent / H₂ / Pd / methanol / 3 h / 760 Torr / Ambient temperature<br />3: 1) tBuOK / 1) THF, -50 deg C, 20 min, 2) THF, -30 deg C, 20 min<br />4: ethyl acetate; diisopropyl ether / 3 h / Ambient temperature<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 98.2 percent / H₂ / Pd / methanol / 3 h / 760 Torr / Ambient temperature<br />2: 1) tBuOK / 1) THF, -50 deg C, 20 min, 2) THF, -30 deg C, 20 min<br />3: ethyl acetate; diisopropyl ether / 3 h / Ambient temperature<br /> <br /> &nbsp;

<b>Multi-step reaction with 5 steps<br /> </b>1: ethyl acetate; diisopropyl ether<br />2: 94 percent / 15percent HCl/dioxane / Ambient temperature<br />3: DCC / tetrahydrofuran / Ambient temperature<br />4: 1) tBuOK / 1) THF, -50 deg C, 20 min, 2) THF, -30 deg C, 20 min<br />5: ethyl acetate; diisopropyl ether / 3 h / Ambient temperature<br /> <br /> &nbsp;