1: pyridine / 24 h 2: 0.16 g / 80percent aq. HOAc / 4.5 h 3: dicyclohexylcarbodiimide / pyridine / 72 h / Ambient temperature 4: 2 M NaOH / 2 h / Ambient temperature View Scheme

1: pyridine / 24 h 2: 0.16 g / 80percent aq. HOAc / 4.5 h 3: dicyclohexylcarbodiimide / pyridine / 72 h / Ambient temperature 4: 86 mg / 2 M NaOH / 2 h / Ambient temperature View Scheme

1: pyridine / 24 h 2: 0.16 g / 80percent aq. HOAc / 4.5 h 3: dicyclohexylcarbodiimide / pyridine / 72 h / Ambient temperature 4: 2 M NaOH / 2 h / Ambient temperature 5: H2 / Lindlar catalyst (poisoned) 6: pyridine / 4.5 h 7: pyridine / 24 h 8: 80percent aq. HOAc / 4.5 h 9: dicyclohexylcarbodiimide / pyridine / 72 h / Ambient temperature 10: 2 M NaOH / 2 h / Ambient temperature View Scheme

1: pyridine / 24 h 2: 0.16 g / 80percent aq. HOAc / 4.5 h 3: dicyclohexylcarbodiimide / pyridine / 72 h / Ambient temperature 4: 2 M NaOH / 2 h / Ambient temperature 5: H2 / Lindlar catalyst (poisoned) View Scheme

<b>Multi-step reaction with 3 steps<br /> </b>1: CuI; Et₃N / (PPh₃)4Pd / dimethylformamide<br />2: K₂CO₃ / methanol<br />3: 92 percent / DMAP; pyridine; Et₃N / 2 h / 20 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>1: CuI; Et₃N / (PPh₃)4Pd / dimethylformamide<br />2: K₂CO₃ / methanol<br />3: 92 percent / DMAP; pyridine; Et₃N / 2 h / 20 &deg;C<br /> <br /> &nbsp;