反应条件
1: With sec.-butyllithium in tetrahydrofuran; hexane; cyclohexane T=-78°C; 0.5 h; Inert atmosphere; 2: With N-fluoro-N-(phenylsulfonyl)benzene-sulfonamide in tetrahydrofuran; hexane; cyclohexane T=-78 - 20°C; Inert atmosphere; 3: With tetrabutyl ammonium fluoride in tetrahydrofuran T=20°C; 3 h; Overall yield = 460 mg;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED; KASAI, Shizuo; IGAWA, Hideyuki; TAKAHASHI, Masashi; MAEKAWA, Tsuyoshi; KAKEGAWA, Keiko; YASUMA, Tsuneo; KINA, Asato; AIDA, Jumpei; KHAMRAI, Uttam; KUNDU, Mrinalkanti
Patent: WO2013/105676 A1, 2013 ;
Location in patent: Page/Page column 272; 273 ;