1: TDA-1, aq. K2CO3 / CH2Cl2 / 24 h / Heating 2: 1.) Br2, 2.) aq. AcOH / 1.) CCl4, 20 deg C, 1 h, 2.) r.t., 10 h 3: 95 percent / NaBH4 / tetrahydrofuran; methanol / 1.5 h / 20 °C 4: 100 percent / NaOMe / methanol / 3 h View Scheme

<b>Multi-step reaction with 2 steps<br /> </b>1: 35percent HBr / acetic acid<br />2: TDA-1, aq. K₂CO₃ / CH₂Cl₂ / 15 h / 40 &deg;C<br /> <br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '8129999', constants.ctx, '0')">silver(l) oxide</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '107477', constants.ctx, '0')">quinoline</a> <br />T=20&deg;C;&nbsp;2&nbsp;h;&nbsp;<br /> &nbsp;