9-苄基-3,9-二氮杂螺[5.5]十一烷-2,4-二酮 (盐酸盐)合成路线 （共 2 条）
反应条件
1: With water; sodium hydroxide T=70°C; 4 h; 2: With hydrogenchloride in water T=45°C; pH=7; 3: With hydrogenchloride in water T=70 - 75°C; pH=3 - 4; Product distribution / selectivity;
参考文献
NEUROGEN CORPORATION; XU, Yuelian; XIE, Linghong; HAN, Bingsong; MAYNARD, George D.; CHENARD, Bertrand, L.; STAAB, Andrew J.
Patent: WO2009/97405 A2, 2009 ;
Location in patent: Page/Page column 15 ;
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=20°C; Reflux; 2: With water in tetrahydrofuran T=20°C;
参考文献
NEUROGEN CORPORATION; XU, Yuelian; XIE, Linghong; HAN, Bingsong; MAYNARD, George D.; CHENARD, Bertrand, L.; STAAB, Andrew J.
Patent: WO2009/97405 A2, 2009 ;
Location in patent: Page/Page column 16 ;
