3-溴-N-甲基咪唑并[1,2-a]吡嗪-8-胺合成路线 （共 4 条）
反应条件
in tetrahydrofuran T=70°C; 3 h;
参考文献
Sugen, Inc.
Patent: US2004/220189 A1, 2004 ;
Location in patent: Page 22 ;
US 20040220189 A1
反应条件
1: bromine / acetic acid 2: H2O / 12 h View Scheme
参考文献
Bonnet, Pierre A.; Michel, Alain; Laurent, Florence; Sablayrolles, Claire; Rechencq, Eliane; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 18 p. 3353 - 3358
参考文献
Bonnet, Pierre A.; Michel, Alain; Laurent, Florence; Sablayrolles, Claire; Rechencq, Eliane; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 18 p. 3353 - 3358
反应条件
hydrogen; palladium 10 on activated carbon in methanol
T=20°C;
参考文献
Sugen, Inc.
Patent: US2004/220189 A1, 2004 ;
Location in patent: Page 53-54 ;
US 20040220189 A1
