吡唑并[1,5-a]吡啶-3-基甲醇合成路线 （共 6 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0°C; 1 h;
参考文献
Gmeiner; Sommer
Archiv der Pharmazie, 1988 , vol. 321, # 9 p. 505 - 507
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 1 h; Ambient temperature;
参考文献
Miki, Yasuyoshi; Nakamura, Noriko; Hachiken, Hiroko; Takemura, Shoji
Journal of Heterocyclic Chemistry, 1989 , vol. 26, p. 1739 - 1745
反应条件
trifluoroacetic acid in dichloromethane 6 h; Heating;
参考文献
Journal of Heterocyclic Chemistry, , vol. 26, p. 1739 - 1745
反应条件
1: Dess-Martin periodane / dichloromethane / 0 - 20 °C / |Inert atmosphere 2: palladium on activated charcoal; hydrogen / ethanol / 20 - 60 °C / |Inert atmosphere View Scheme
参考文献
ENVIVO PHARMACEUTICALS, INC.; RIPKA, Amy; SHAPIRO, Gideon; MCRINER, Andrew, J.; BURSAVICH, Matthew, Gregory
Patent: WO2013/142269 A1, 2013 ;
反应条件
manganese(IV) oxide in tetrahydrofuran 1.5 h; Reflux;
参考文献
ENVIVO PHARMACEUTICALS, INC.; RIPKA, Amy; SHAPIRO, Gideon; MCRINER, Andrew, J.; BURSAVICH, Matthew, Gregory
Patent: WO2013/142269 A1, 2013 ;
Location in patent: Paragraph 0709; 0710; 0711 ;
反应条件
1: 95.5 percent / pyridine / 1 h / Ambient temperature 2: 92.4 percent / acetonitrile / 5 h / 160 °C View Scheme
参考文献
Gmeiner; Schuenemann
Archiv der Pharmazie, 1988 , vol. 321, # 9 p. 517 - 520
