4-(3-吡啶)-1H-吡唑-3-羧酸合成路线 （共 5 条）
反应条件
hydrogenchloride in water 3 h; Reflux;
参考文献
Janin, Yves L.
Journal of Heterocyclic Chemistry, 2013 , vol. 50, # 6 p. 1410 - 1414
反应条件
potassium hydroxide T=65°C; 0.5 h;
参考文献
Cativiela, Carlos; Villegas, Maria D. Diaz de; Mayoral, Jose A.; Avenoza, Alberto; Roy, Miguel A.
Journal of Heterocyclic Chemistry, 1988 , vol. 25, p. 851 - 855
反应条件
1: 48 percent / CH3ONa / Ambient temperature 2: 90 percent / CHCl3 / Ambient temperature 3: 73 percent / BF3*Et2O / CHCl3 / 0.5 h / Heating 4: 68 percent / 10percent methanolic KOH / 0.5 h / 65 °C View Scheme
参考文献
Cativiela, Carlos; Villegas, Maria D. Diaz de; Mayoral, Jose A.; Avenoza, Alberto; Roy, Miguel A.
Journal of Heterocyclic Chemistry, 1988 , vol. 25, p. 851 - 855
反应条件
1.1: potassium hydroxide / water; diethyl ether / 0.17 h / 0 °C 1.2: 0 - 25 °C 2.1: bromine / diethyl ether / 0.17 h / 25 °C 3.1: hydrogenchloride / water / 3 h / |Reflux View Scheme
参考文献
Janin, Yves L.
Journal of Heterocyclic Chemistry, 2013 , vol. 50, # 6 p. 1410 - 1414
反应条件
1.1: sulfuric acid / 36 h / |Reflux 2.1: potassium hydroxide / water; diethyl ether / 0.17 h / 0 °C 2.2: 0 - 25 °C 3.1: bromine / diethyl ether / 0.17 h / 25 °C 4.1: hydrogenchloride / water / 3 h / |Reflux View Scheme
参考文献
Janin, Yves L.
Journal of Heterocyclic Chemistry, 2013 , vol. 50, # 6 p. 1410 - 1414
