N-乙酰基-L-天冬氨酸 4-叔丁酯合成路线 （共 4 条）
反应条件
in tetrahydrofuran T=20°C; 16 h;
参考文献
Goode, David R.; Sharma, Anil K.; Hergenrother, Paul J.
Organic Letters, 2005 , vol. 7, # 16 p. 3529 - 3532
反应条件
1: N-(9-fluorenylmethoxycarbonyl)-L-aspartic acid-β-(tert-butyl)ester With N-ethyl-N,N-diisopropylamine in methanol; dichloromethane 1.25 h; 2: With piperidine; 1,8-diazabicyclo[5.4.0]undec-7-ene in N,N-dimethyl-formamide 0.25 h; 3: acetic anhydride Further stages;
参考文献
WO2014/56923 A1, ;
Page/Page column 146; 147 ;
反应条件
triethylamine in water; N,N-dimethyl-formamide T=20°C; 24 h;
参考文献
Piotrovskii, L. B.; Dumpis, M. A.; Poznyakova, L. N.; Aleksandrova, L. N.; Sepetov, N. F.
Journal of Organic Chemistry USSR (English Translation), 1988 , vol. 24, p. 96 - 100
Zhurnal Organicheskoi Khimii, 1988 , vol. 24, # 1 p. 111 - 116
反应条件
1: 43 percent / triethylamine / dimethylformamide / 48 h / 20 °C
2: 72 percent / trifluoroacetic acid / 0.5 h / 20 °C
3: N-methylmorpholine / ethyl acetate / 0.03 h / -15 °C
4: N-methylmorpholine / ethyl acetate; dimethylformamide / 40 min at -15 deg C, then 1 h at 10 deg C
5: 85 percent / hydrogen / Pd/C / ethanol; H2O; acetic acid
View Scheme
参考文献
Piotrovskii, L. B.; Dumpis, M. A.; Poznyakova, L. N.; Aleksandrova, L. N.; Sepetov, N. F.
Journal of Organic Chemistry USSR (English Translation), 1988 , vol. 24, p. 96 - 100
Zhurnal Organicheskoi Khimii, 1988 , vol. 24, # 1 p. 111 - 116
