5-(2-羟基乙基)-2-吗啉嘧啶-4,6-二醇合成路线 （共 5 条）
反应条件
sodium methylate in methanol Reflux;
参考文献
Ohwada, Jun; Ebiike, Hirosato; Kawada, Hatsuo; Tsukazaki, Masao; Nakamura, Mitsuaki; Miyazaki, Takuya; Morikami, Kenji; Yoshinari, Kiyoshi; Yoshida, Miyuki; Kondoh, Osamu; Kuramoto, Shino; Ogawa, Kotaro; Aoki, Yuko; Shimma, Nobuo
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 6 p. 1767 - 1772
反应条件
sodium in methanol 2 h; Reflux;
参考文献
Kawada, Hatsuo; Ebiike, Hirosato; Tsukazaki, Masao; Nakamura, Mitsuaki; Morikami, Kenji; Yoshinari, Kiyoshi; Yoshida, Miyuki; Ogawa, Kotaro; Shimma, Nobuo; Tsukuda, Takuo; Ohwada, Jun
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 3 p. 673 - 678
反应条件
N-ethyl-N,N-diisopropylamine; trichlorophosphate in water; toluene T=0 - 100°C; 7 h;
参考文献
Chugai Seiyaku Kabushiki Kaisha
Patent: EP2239261 A1, 2010 ;
Location in patent: Page/Page column 28 ;
反应条件
1: triethyl amine hydrochloride; trichlorophosphate / toluene / 90 °C 2: potassium carbonate / 1-methyl-pyrrolidin-2-one / 100 °C 3: bis-triphenylphosphine-palladium(II) chloride; potassium phosphate / N,N-dimethyl-formamide / 60 °C View Scheme
参考文献
Ohwada, Jun; Ebiike, Hirosato; Kawada, Hatsuo; Tsukazaki, Masao; Nakamura, Mitsuaki; Miyazaki, Takuya; Morikami, Kenji; Yoshinari, Kiyoshi; Yoshida, Miyuki; Kondoh, Osamu; Kuramoto, Shino; Ogawa, Kotaro; Aoki, Yuko; Shimma, Nobuo
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 6 p. 1767 - 1772
反应条件
1: triethyl amine hydrochloride; trichlorophosphate / toluene / 90 °C 2: potassium carbonate / 1-methyl-pyrrolidin-2-one / 100 °C View Scheme
参考文献
Ohwada, Jun; Ebiike, Hirosato; Kawada, Hatsuo; Tsukazaki, Masao; Nakamura, Mitsuaki; Miyazaki, Takuya; Morikami, Kenji; Yoshinari, Kiyoshi; Yoshida, Miyuki; Kondoh, Osamu; Kuramoto, Shino; Ogawa, Kotaro; Aoki, Yuko; Shimma, Nobuo
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 6 p. 1767 - 1772
