4-氯-6,7-二氢-7-(甲基磺酰基)-2-(4-吗啉)-5H-吡咯并[2,3-d]嘧啶合成路线 （共 4 条）
反应条件
potassium carbonate in 1-methyl-pyrrolidin-2-one T=100°C;
参考文献
Ohwada, Jun; Ebiike, Hirosato; Kawada, Hatsuo; Tsukazaki, Masao; Nakamura, Mitsuaki; Miyazaki, Takuya; Morikami, Kenji; Yoshinari, Kiyoshi; Yoshida, Miyuki; Kondoh, Osamu; Kuramoto, Shino; Ogawa, Kotaro; Aoki, Yuko; Shimma, Nobuo
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 6 p. 1767 - 1772
反应条件
1: triethyl amine hydrochloride; trichlorophosphate / toluene / 90 °C 2: potassium carbonate / 1-methyl-pyrrolidin-2-one / 100 °C View Scheme
参考文献
Ohwada, Jun; Ebiike, Hirosato; Kawada, Hatsuo; Tsukazaki, Masao; Nakamura, Mitsuaki; Miyazaki, Takuya; Morikami, Kenji; Yoshinari, Kiyoshi; Yoshida, Miyuki; Kondoh, Osamu; Kuramoto, Shino; Ogawa, Kotaro; Aoki, Yuko; Shimma, Nobuo
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 6 p. 1767 - 1772
反应条件
1: sodium methylate / methanol / Reflux 2: triethyl amine hydrochloride; trichlorophosphate / toluene / 90 °C 3: potassium carbonate / 1-methyl-pyrrolidin-2-one / 100 °C View Scheme
参考文献
Ohwada, Jun; Ebiike, Hirosato; Kawada, Hatsuo; Tsukazaki, Masao; Nakamura, Mitsuaki; Miyazaki, Takuya; Morikami, Kenji; Yoshinari, Kiyoshi; Yoshida, Miyuki; Kondoh, Osamu; Kuramoto, Shino; Ogawa, Kotaro; Aoki, Yuko; Shimma, Nobuo
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 6 p. 1767 - 1772
反应条件
potassium phosphate; bis-triphenylphosphine-palladium(II) chloride in water; N,N-dimethyl-formamide T=60°C; 2 h; Inert atmosphere;
参考文献
Chugai Seiyaku Kabushiki Kaisha
Patent: EP2239261 A1, 2010 ;
Location in patent: Page/Page column 38-39 ;
