1,1,1-三氟-4-(4-羟基苯基)丁烷-2-酮合成路线 （共 5 条）
反应条件
boron tribromide in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; diethyl ether; dichloromethane
参考文献
Bristol-Myers Squibb Company
Patent: US6255496 B1, 2001 ;
反应条件
hydrogen bromide in water; acetic acid; ethyl acetate
参考文献
Becton, Dickinson and Company
Patent: US5344952 A1, 1994 ;
反应条件
pyridine in dichloromethane
T=-50 - -20°C; Substitution; 5 h;
参考文献
Yang, Dan; Wong, Man-Kin; Yan, Zheng
Journal of Organic Chemistry, 2000 , vol. 65, # 13 p. 4179 - 4184
反应条件
1: oxalyl chloride / CH2Cl2 / 20 °C
2: pyridine / CH2Cl2 / 5 h / -50 - -20 °C
View Scheme
参考文献
Yang, Dan; Wong, Man-Kin; Yan, Zheng
Journal of Organic Chemistry, 2000 , vol. 65, # 13 p. 4179 - 4184
反应条件
1: oxalyl chloride / CH2Cl2 / 2 h / 20 °C
2: 600 mg / pyridine / CH2Cl2 / 4 h / -20 °C
3: 55 percent / K2CO3 / methanol; H2O / 3 h / 20 °C
View Scheme
参考文献
Yang, Dan; Wong, Man-Kin; Yan, Zheng
Journal of Organic Chemistry, 2000 , vol. 65, # 13 p. 4179 - 4184
