(R)-boc-5,5-二甲基-1,3-噻唑烷-4-羧酸合成路线 （共 7 条）
反应条件
sodium hydroxide in isopropyl alcohol
参考文献
Lu, Zhijian; Raghavan, Subharekha; Bohn, Joann; Charest, Mark; Stahlhut, Mark W.; Rutkowski, Carrie A.; Simcoe, Amy L.; Olsen, David B.; Schleif, William A.; Carella, Anthony; Gabryelski, Lori; Jin, Lixia; Lin, Jiunn H.; Emini, Emilio; Chapman, Kevin; Tata, James R.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 10 p. 1821 - 1824
反应条件
1: methyl (+/-)-5,5-dimethyl-1,3-thiazolidine-4-carboxylate With Klebsiella oxytoca hydrolase in water T=60°C; 26 h; 2: With sodium hydroxide pH=11.5; 3: di-tert-butyl dicarbonate in sodium hydroxide; isopropyl alcohol T=20°C; 4 h;
参考文献
Ikunaka, Masaya; Matsumoto, Jun; Nishimoto, Yukifumi
Tetrahedron Asymmetry, 2002 , vol. 13, # 11 p. 1201 - 1208
反应条件
1: H2O 2: aq. NaOH / tetrahydrofuran View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 42, # 10 p. 1789 - 1802
反应条件
1.1: 96.4 percent / ethanol; H2O / 21 h / 20 °C 2.1: 84 percent / HCl / 4 h / Heating 3.1: Klebsiella oxytoca hydrolase / H2O / 26 h / 60 °C 3.2: aq. NaOH / various solvent(s) / pH 11.5 3.3: 23.6 percent / aq. NaOH; propan-2-ol / 4 h / 20 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 13, # 11 p. 1201 - 1208
反应条件
1.1: 84 percent / HCl / 4 h / Heating 2.1: Klebsiella oxytoca hydrolase / H2O / 26 h / 60 °C 2.2: aq. NaOH / various solvent(s) / pH 11.5 2.3: 23.6 percent / aq. NaOH; propan-2-ol / 4 h / 20 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 13, # 11 p. 1201 - 1208
反应条件
1: 1.) Et3N, DPP-Cl, 2.) Et3N / 1.) EtOAc, 0 deg C, 1 h, 2.) EtOAc, overnight 2: 4 N HCl / dioxane / 2 h 3: HOBt, EDC*HCl / dimethylformamide 4: 4 N HCl / CH2Cl2; dioxane / 3 h 5: 1.) Et3N, DPP-Cl, 2.) Et3N / 1.) EtOAc, 0 deg C, 1 h, 2.) EtOAc, overnight 6: 1 N NaOH / methanol / 1 h View Scheme
参考文献
Mimoto, Tsutomu; Kato, Ryohei; Takaku, Haruo; Nojima, Satoshi; Terashima, Keisuke; Misawa, Satoru; Fukazawa, Tominaga; Ueno, Takamasa; Sato, Hideharu; Shintani, Makoto; Kiso, Yoshiaki; Hayashi, Hideya
Journal of Medicinal Chemistry, 1999 , vol. 42, # 10 p. 1789 - 1802
反应条件
1: DCC / tetrahydrofuran / 1 h / 0 °C
2: tetrahydrofuran
3: 4 N HCl / dioxane / 2 h
4: HOBt, DCC / dimethylformamide
5: 4 N HCl / CH2Cl2; dioxane / 2 h
6: 92 percent / HOBt*H2O, EDC*HCl / dimethylformamide
View Scheme
参考文献
Mimoto, Tsutomu; Kato, Ryohei; Takaku, Haruo; Nojima, Satoshi; Terashima, Keisuke; Misawa, Satoru; Fukazawa, Tominaga; Ueno, Takamasa; Sato, Hideharu; Shintani, Makoto; Kiso, Yoshiaki; Hayashi, Hideya
Journal of Medicinal Chemistry, 1999 , vol. 42, # 10 p. 1789 - 1802
