2-[[[4-(3-甲氧基丙氧基)-3-甲基吡啶-2-基]甲基]硫代]-1H-苯并咪唑合成路线 （共 17 条）
反应条件
sodium hydroxide in ethanol T=50°C; 2 h; Product distribution / selectivity;
参考文献
EP1775292 A1, ;
Page/Page column 13; 14 ;
反应条件
sodium hydroxide in water; acetone T=15 - 20°C; 0.75 h;
参考文献
Synthetic Communications, , vol. 39, # 2 p. 278 - 290
反应条件
potassium hydroxide in dimethyl sulfoxide T=20°C; 336 h;
参考文献
Journal of Heterocyclic Chemistry, , vol. 43, # 6 p. 1447 - 1453
反应条件
1: 75 percent / phosphorus oxychloride / CH2Cl2 / 20 °C 2: 52 percent / CH2Cl2 / 12 h / Heating 3: 69 percent / triethylamine / acetonitrile / 18 h / 20 °C 4: 29.5 percent / potassium hydroxide / dimethylsulfoxide / 336 h / 20 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 43, # 6 p. 1447 - 1453
反应条件
1: 52 percent / CH2Cl2 / 12 h / Heating 2: 69 percent / triethylamine / acetonitrile / 18 h / 20 °C 3: 29.5 percent / potassium hydroxide / dimethylsulfoxide / 336 h / 20 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 43, # 6 p. 1447 - 1453
反应条件
1: 52 percent / triethylamine / acetonitrile / 20 °C 2: 29.5 percent / potassium hydroxide / dimethylsulfoxide / 336 h / 20 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 43, # 6 p. 1447 - 1453
反应条件
citrate buffer in acetonitrile T=25°C; 0.25 h; also omeprazole; var. pH, var. time; Product distributionMechanism;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 44, # 3 p. 552 - 558
反应条件
1: With sodium hydroxide; sodium hypochlorite in pyridine; water T=5 - 8°C; 4 h; 2: With sodium hydroxide; ammonia in methanol; ethyl acetate
参考文献
WO2004/63188 A1, ;
Page 13 ;
反应条件
carbon in methanol 0.5 h;
参考文献
WO2008/45777 A2, ;
Page/Page column 32 ;
反应条件
sodium hydroxide; N-chloro-succinimide; water in acetonitrile T=0 - 5°C; 2 h; Product distribution / selectivity;
参考文献
WO2006/24890 A1, ;
Page/Page column 6-7 ;
