反应条件
1: 4.35 g / pyridine / CH2Cl2 / 0.33 h / ice-cooling 2: 1) sodium hydride / 1) THF, 2) THF, room temperature, 16 h 3: 65.5 percent / NH2OH*HCl / ethanol / Heating 4: 63 percent / tetrahydrofuran / 5 h / Ambient temperature View Scheme
参考文献
Bedford; Harris III; Howd; Goff; Koolpe; Petesch; Koplovitz; Sultan; Musallam
Journal of Medicinal Chemistry, 1989 , vol. 32, # 2 p. 504 - 516
