3,4,5-三甲氧基苯甲酸合成路线 （共 210 条）
反应条件
1: sulfuric acid / 8.5 h / 20 °C / |Reflux 2: nitric acid / acetic acid / 1 h / 20 °C / |Cooling with ice 3: SnCl2·2H2O; hydrogenchloride / ethanol / |Inert atmosphere; |Reflux 4: sodium hydroxide; water / ethanol / 45 - 50 °C 5: 5 h / 130 - 140 °C View Scheme
参考文献
Zhang, Zhichao; Liang, Xiaomeng; Li, Xiangqian; Song, Ting; Chen, Qingbin; Sheng, Hongkun
European Journal of Medicinal Chemistry, 2013 , vol. 69, p. 711 - 718
反应条件
sodium hydroxide T=200°C;
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 15, p. 639,643
反应条件
sodium tetrahydroborate; sodium sulfate; dihydroxy(3,4,5-trifluorophenyl)borane in tetrahydrofuran T=20°C; 10 h;
参考文献
Tale; Patil; Dapurkar
Tetrahedron Letters, 2003 , vol. 44, # 16 p. 3427 - 3428
反应条件
1: sulfuric acid / 40 - 50 °C 2: NaOH-solution 3: benzene; phosphorus pentachloride / 0 °C 4: alcohol; diethyl ether 5: ammonium chloride; diluted ammonia 6: water / 175 - 180 °C 7: hydrogen bromide; glacial acetic acid / bei gewoehnlicher Temperatur View Scheme
参考文献
Bradley; Robinson
Journal of the Chemical Society, 1928 , p. 1551
反应条件
1: sulfuric acid / 40 - 50 °C 2: NaOH-solution View Scheme
参考文献
Bradley; Robinson
Journal of the Chemical Society, 1928 , p. 1551
反应条件
1,4-dioxane; diethyl ether
参考文献
Anderson; Greef
Journal of the American Chemical Society, 1952 , vol. 74, p. 2923
反应条件
1: SOCl2 / 0.5 h / Heating 2: Et3N / CHCl3 / 2 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 40, # 1 p. 202 - 211
反应条件
thionyl chloride; N,N-dimethyl-formamide Reagent/catalyst;
参考文献
Organic Process Research and Development, , vol. 17, # 7 p. 981 - 984
反应条件
1: HCl 2: LiAlH4 / tetrahydrofuran View Scheme
参考文献
Sugihara,H. et al.
Justus Liebigs Annalen der Chemie, 1972 , vol. 763, p. 109 - 120
反应条件
sodium; tert-butyl alcohol 3.5 h; Heating;
参考文献
Sharda, Rekha; Krishnamurty, H. G.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 5 p. 405 - 406
