3,4,5-三甲氧基苯甲酸合成路线 （共 210 条）
反应条件
1.1: 90 percent / methanesulfonyl chloride; Et3N / tetrahydrofuran / 0 °C 2.1: Et3N / 0.08 h / Heating 2.2: 62 percent / KOH / methanol / 0.33 h / sonication View Scheme
参考文献
Daskiewicz, Jean-Baptiste; Depeint, Flore; Viornery, Lionel; Bayet, Christine; Comte-Sarrazin, Geraldine; Comte, Gilles; Gee, Jennifer M.; Johnson, Ian T.; Ndjoko, Karine; Hostettmann, Kurt; Barron, Denis
Journal of Medicinal Chemistry, 2005 , vol. 48, # 8 p. 2790 - 2804
反应条件
bromine in chloroform; water 18 h; Heating;
参考文献
AMAZENTIS SA; RINSCH, Christopher, L.; BLANCO-BOSE, William; SCHNEIDER, Bernard; MOUCHIROUD, Laurent; RYU, Dongryeol; ANDREUX, Penelope; AUWERX, Johan
Patent: WO2014/4902 A2, 2014 ;
Location in patent: Sheet 35 ;
反应条件
sodium azide; chloroform; sulfuric acid
参考文献
Vereshchagin, A. L.; Bryanskii, O. V.; Semenov, A. A.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1983 , p. 40 - 42
Khimiya Geterotsiklicheskikh Soedinenii, 1983 , vol. 19, # 1 p. 46 - 48
反应条件
1: diethyl ether; dioxane 2: NaH; dibutyl ether View Scheme
参考文献
Li, Yao-Wu; Liu, Jia; Liu, Na; Shi, Duo; Zhou, Xiao-Tian; Lv, Jia-Guo; Zhu, Ju; Zheng, Can-Hui; Zhou, You-Jun
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 11 p. 3579 - 3584
反应条件
1: 92 percent / SOCl2 / 5 h / Heating 2: 90 percent / ZnCl2 / benzene / 12 h / Ambient temperature 3: 1.) NH2NH2; 2.) KOH / 1.) EtOH, reflux, 5 h; 2.) 180 deg C, 1 h 4: 82 percent / potassium / tetrahydrofuran / 24 h / Ambient temperature View Scheme
参考文献
Azzena, Ugo; Denurra, Teresa; Melloni, Giovanni; Rassu, Gloria
Journal of the Chemical Society, Chemical Communications, 1987 , p. 1549 - 1550
反应条件
1: 92 percent / SOCl2 / 5 h / Heating 2: 90 percent / ZnCl2 / benzene / 12 h / Ambient temperature View Scheme
参考文献
Azzena, Ugo; Denurra, Teresa; Melloni, Giovanni; Rassu, Gloria
Journal of the Chemical Society, Chemical Communications, 1987 , p. 1549 - 1550
反应条件
1: HCl 2: LiAlH4 / tetrahydrofuran View Scheme
参考文献
Sugihara,H. et al.
Justus Liebigs Annalen der Chemie, 1972 , vol. 763, p. 109 - 120
反应条件
1: 92 percent / SOCl2 / 5 h / Heating 2: 90 percent / ZnCl2 / benzene / 12 h / Ambient temperature 3: 1.) NH2NH2; 2.) KOH / 1.) EtOH, reflux, 5 h; 2.) 180 deg C, 1 h View Scheme
参考文献
Azzena, Ugo; Denurra, Teresa; Melloni, Giovanni; Rassu, Gloria
Journal of the Chemical Society, Chemical Communications, 1987 , p. 1549 - 1550
反应条件
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine in dichloromethane T=0°C; Inert atmosphere;
参考文献
Brachet, Etienne; Hamze, Abdallah; Peyrat, Jean-Francois; Brion, Jean-Daniel; Alami, Mouad
Organic Letters, 2010 , vol. 12, # 18 p. 4042 - 4045
反应条件
1: acetonitrile / 0.33 h / 20 °C 2: triethylamine / acetonitrile / 20 h / 40 °C View Scheme
参考文献
Titov, Ilia Y.; Sagamanova, Irina K.; Gritsenko, Roman T.; Karmanova, Irina B.; Atamanenko, Olga P.; Semenova, Marina N.; Semenov, Victor V.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 6 p. 1578 - 1581
