3,4,5-三甲氧基苯甲酸合成路线 （共 210 条）
反应条件
1: 89 percent / H2SO4
2: 84 percent / Br2 / CHCl3
View Scheme
参考文献
Michalsky,J.; Smrz,M.
Monatshefte fuer Chemie, 1960 , vol. 91, p. 307 - 312
参考文献
Sarbhai,K.P.; Mathur,K.B.L.
Indian Journal of Chemistry, 1966 , vol. 4, p. 81 - 85
反应条件
1: conc. H2SO4 / 20 h / Heating
2: H2NNH2*H2O / 6 h / Heating
3: ethanol / 4 h / Heating
4: 93 percent / aq. NaOH / 3 h / Heating
View Scheme
参考文献
Abdel-Aziz, Mohamed; Abuo-Rahma, Gamal El-Din A.A.; Beshr, Eman A.M.; Ali, Taha F.S.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 13 p. 3839 - 3849
反应条件
1: 96 percent / Br2 / H2O; CHCl3 / 18 h / Heating
2: 90 percent / Cu powder / methanol / 18 h / Heating
View Scheme
参考文献
AMAZENTIS SA; RINSCH, Christopher, L.; BLANCO-BOSE, William; SCHNEIDER, Bernard; MOUCHIROUD, Laurent; RYU, Dongryeol; ANDREUX, Penelope; AUWERX, Johan
Patent: WO2014/4902 A2, 2014 ;
反应条件
1: iron-powder; CHCl3; bromine
View Scheme
参考文献
Friedrich; Mirbach
Chemische Berichte, 1959 , vol. 92, p. 2574,2575, 2577
反应条件
sodium tetrahydroborate; zirconium tetrachloride in tetrahydrofuran
12 h;
参考文献
Meyers; Nelson, Todd D.; Moorlag, Henk; Rawson, David J.; Meier, Anton
Tetrahedron, 2004 , vol. 60, # 20 p. 4459 - 4473
反应条件
1: sulfuric acid / 40 - 50 °C
2: NaOH-solution
3: benzene; phosphorus pentachloride / 0 °C
4: alcohol; diethyl ether
5: ammonium chloride; diluted ammonia
6: water / 175 - 180 °C
View Scheme
参考文献
Bradley; Robinson
Journal of the Chemical Society, 1928 , p. 1551
反应条件
1: thionyl chloride
2: diethyl ether; chloroform / -10 °C
View Scheme
参考文献
Hayashi
Acta Phytochimica, 1934 , vol. 8, p. 65,81
反应条件
hydrogenchloride in water
T=60 - 70°C; 7 h;
参考文献
Bhattacharjee, Debkumar; Popp, Frank D.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 315 - 320
反应条件
1.1: sulfuric acid / 8 h / Reflux
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / -78 - -30 °C / Inert atmosphere
2.2: -78 - 20 °C / Inert atmosphere
3.1: Dowex-H / isopropyl alcohol / Reflux
View Scheme
参考文献
Verma, Alok K.; Singh, Himanshu; Satyanarayana, Mavurapu; Srivastava, Swayam P.; Tiwari, Priti; Singh, Amar B.; Dwivedi, Anil K.; Singh, Shio K.; Srivastava, Mukesh; Nath, Chandishwar; Raghubir, Ram; Srivastava, Arvind K.; Pratap, Ram
Journal of Medicinal Chemistry, 2012 , vol. 55, # 10 p. 4551 - 4567
