3,4,5-三甲氧基苯甲酸合成路线 (共 210 条)
反应条件
phosphorus trichoride in xylene
T=103 - 106°C; 6 h;
参考文献
Voronon, V. G.; Shramova, Z. I.; Aleshina, V. A.; Zaks, A. S.; Pidemskii, E. L.; Goleneva, A. F.
Pharmaceutical Chemistry Journal, 1981 , vol. 15, # 6 p. 396 - 399
Khimiko-Farmatsevticheskii Zhurnal, 1981 , vol. 15, # 6 p. 35 - 39
反应条件
phosphorus pentachloride
T=175 - 180°C; 0.666667 h;
参考文献
Voronon, V. G.; Shramova, Z. I.; Aleshina, V. A.; Zaks, A. S.; Pidemskii, E. L.; Goleneva, A. F.
Pharmaceutical Chemistry Journal, 1981 , vol. 15, # 6 p. 396 - 399
Khimiko-Farmatsevticheskii Zhurnal, 1981 , vol. 15, # 6 p. 35 - 39
反应条件
1: 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl; 4-(dimethylamino)pyridine / dimethylformamide / 25 °C
2: CH3COONH4; CH3COOH / 8 h / Heating
View Scheme
参考文献
Yamane, Taihei; Mitsudera, Hiroyuki; Shundoh, Takatsugu
Synthesis, 2004 , # 17 p. 2825 - 2832
反应条件
methanesulfonic acid; phosphorous pentoxide
T=40°C; 4 h;
参考文献
Petrov, Ognyan I.; Gerova, Mariana S.; Chanev, Christo D.; Petrova, Katya V.
Synthesis, 2011 , # 22 art. no. Z71911SS, p. 3711 - 3715
反应条件
1: oxalyl dichloride
2: acetone / 0.33 h / Inert atmosphere; Reflux
View Scheme
参考文献
Solinas, Antonio; Faure, Helene; Roudaut, Hermine; Traiffort, Elisabeth; Schoenfelder, Angele; Mann, Andre; Manetti, Fabrizio; Taddei, Maurizio; Ruat, Martial
Journal of Medicinal Chemistry, 2012 , vol. 55, # 4 p. 1559 - 1571
反应条件
1: oxalyl chloride / N,N-dimethylformamide / CH2Cl2
2: 3.02 g / N-ethyl-N,N-diisopropylamine / CH2Cl2
View Scheme
参考文献
Elsinghorst, Paul W.; Gonzalez Tanarro, Camino M.; Guetschow, Michael
Journal of Medicinal Chemistry, 2006 , vol. 49, # 25 p. 7540 - 7544
反应条件
1: oxalyl chloride / N,N-dimethylformamide / CH2Cl2
2: 2.91 g / N-ethyl-N,N-diisopropylamine / CH2Cl2
View Scheme
参考文献
Elsinghorst, Paul W.; Gonzalez Tanarro, Camino M.; Guetschow, Michael
Journal of Medicinal Chemistry, 2006 , vol. 49, # 25 p. 7540 - 7544
反应条件
1: oxalyl chloride / N,N-dimethylformamide / CH2Cl2
2: 3.05 g / N-ethyl-N,N-diisopropylamine / CH2Cl2
View Scheme
参考文献
Elsinghorst, Paul W.; Gonzalez Tanarro, Camino M.; Guetschow, Michael
Journal of Medicinal Chemistry, 2006 , vol. 49, # 25 p. 7540 - 7544
反应条件
1: oxalyl chloride / N,N-dimethylformamide / CH2Cl2
2: 3.24 g / N-ethyl-N,N-diisopropylamine / CH2Cl2 / 1 h
View Scheme
参考文献
Elsinghorst, Paul W.; Gonzalez Tanarro, Camino M.; Guetschow, Michael
Journal of Medicinal Chemistry, 2006 , vol. 49, # 25 p. 7540 - 7544
反应条件
1: oxalyl chloride / N,N-dimethylformamide / CH2Cl2
2: 3.02 g / N-ethyl-N,N-diisopropylamine / CH2Cl2
3: 71 percent / hydrazine hydrate / ethanol / 24 h / Heating
View Scheme
参考文献
Elsinghorst, Paul W.; Gonzalez Tanarro, Camino M.; Guetschow, Michael
Journal of Medicinal Chemistry, 2006 , vol. 49, # 25 p. 7540 - 7544