3,4,5-三甲氧基苯甲酸合成路线 （共 210 条）
反应条件
1: oxalyl chloride / N,N-dimethylformamide / CH2Cl2
2: 2.20 g / N-ethyl-N,N-diisopropylamine / CH2Cl2
3: 80 percent / hydrazine hydrate / ethanol / 24 h / Heating
View Scheme
参考文献
Elsinghorst, Paul W.; Gonzalez Tanarro, Camino M.; Guetschow, Michael
Journal of Medicinal Chemistry, 2006 , vol. 49, # 25 p. 7540 - 7544
反应条件
1: oxalyl chloride / N,N-dimethylformamide / CH2Cl2
2: 2.91 g / N-ethyl-N,N-diisopropylamine / CH2Cl2
3: 66 percent / hydrazine hydrate / ethanol / 24 h / Heating
View Scheme
参考文献
Elsinghorst, Paul W.; Gonzalez Tanarro, Camino M.; Guetschow, Michael
Journal of Medicinal Chemistry, 2006 , vol. 49, # 25 p. 7540 - 7544
反应条件
1: oxalyl chloride / N,N-dimethylformamide / CH2Cl2
2: 3.05 g / N-ethyl-N,N-diisopropylamine / CH2Cl2
3: 65 percent / hydrazine hydrate / ethanol / 24 h / Heating
View Scheme
参考文献
Elsinghorst, Paul W.; Gonzalez Tanarro, Camino M.; Guetschow, Michael
Journal of Medicinal Chemistry, 2006 , vol. 49, # 25 p. 7540 - 7544
反应条件
1: oxalyl chloride / N,N-dimethylformamide / CH2Cl2
2: 3.24 g / N-ethyl-N,N-diisopropylamine / CH2Cl2 / 1 h
3: 77 percent / hydrazine hydrate / ethanol / 24 h / Heating
View Scheme
参考文献
Elsinghorst, Paul W.; Gonzalez Tanarro, Camino M.; Guetschow, Michael
Journal of Medicinal Chemistry, 2006 , vol. 49, # 25 p. 7540 - 7544
反应条件
1.) SOCl2, C6H6, reflux 6 h; 2.) CHCl3; Yield given. Multistep reaction;
参考文献
Bartl; Svatek; Dlabac; et al.
Collection of Czechoslovak Chemical Communications, 1984 , vol. 49, # 8 p. 1816 - 1826
反应条件
iodine; silver trifluoroacetate in chloroform
3 h;
参考文献
Molander, Gary A.; George, Kelly M.; Monovich, Lauren G.
Journal of Organic Chemistry, 2003 , vol. 68, # 25 p. 9533 - 9540
反应条件
1: benzene; PCl5 / man leitet dann Ammoniak ein
2: hypochlorite; sodium hydroxide / unter Eiszusatz
3: Acetylierung
View Scheme
参考文献
Graebe; Suter
Justus Liebigs Annalen der Chemie, 1905 , vol. 340, p. 230
反应条件
1: 5.8 g / HCl(g) / 5 °C
2: KMnO4
View Scheme
参考文献
Duggal, J. Kaur; Misra, K.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 11 p. 1000 - 1001
反应条件
1: oxalyl chloride / N,N-dimethylformamide / CH2Cl2
2: 2.20 g / N-ethyl-N,N-diisopropylamine / CH2Cl2
View Scheme
参考文献
Elsinghorst, Paul W.; Gonzalez Tanarro, Camino M.; Guetschow, Michael
Journal of Medicinal Chemistry, 2006 , vol. 49, # 25 p. 7540 - 7544
反应条件
1: oxalyl chloride / CH2Cl2; dimethylformamide / 2 h / Heating
2: pyridine / CH2Cl2 / 20 h
View Scheme
参考文献
Keck, Gary E; McLaws, Mark D; Wager, Travis T
Tetrahedron, 2000 , vol. 56, # 51 p. 9875 - 9883
