3,4,5-三甲氧基苯甲酸合成路线 （共 210 条）
反应条件
oxalyl dichloride
1.) DMF, ether, ice cooling, 4 h, 2.) ether, ice cooling, 24 h; Yield givenMultistep reaction;
参考文献
Berg; Bladh
Acta chemica Scandinavica (Copenhagen, Denmark : 1989), 1998 , vol. 52, # 12 p. 1380 - 1385
反应条件
1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 0 °C
2: triethylamine / dichloromethane / 0 °C
View Scheme
参考文献
Kong, Wangqing; Casimiro, Maria; Fuentes, Noelia; Merino, Estibaliz; Nevado, Cristina
Angewandte Chemie - International Edition, 2013 , vol. 52, # 49 p. 13086 - 13090
Angew. Chem., 2013 , vol. 125, # 49 p. 13324 - 13328,5
反应条件
2,4,6-trichloro-1,3,5-triazine
参考文献
Beugelmans, Rene; Ginsburg, Helene; Bois-Choussy, Michele
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 1149 - 1152
反应条件
1: SOCl2 / CHCl3 / Heating
2: Et3N / CH2Cl2
View Scheme
参考文献
Gita, Haruhisa; Sobe, Yoshiaki; Akaku, Haruo; Ekine, Rena; Oto, Yuso; Isawa, Satoru; Hayashi, Hideya
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 4 p. 549 - 551
反应条件
1: hydrogen chloride
3: acetic acid; ozone / 60 °C
View Scheme
参考文献
Bogert; Isham
Journal of the American Chemical Society, 1914 , vol. 36, p. 518
反应条件
1: oxalyl chloride / N,N-dimethylformamide / CH2Cl2
2: 2.47 g / N-ethyl-N,N-diisopropylamine / CH2Cl2
View Scheme
参考文献
Elsinghorst, Paul W.; Gonzalez Tanarro, Camino M.; Guetschow, Michael
Journal of Medicinal Chemistry, 2006 , vol. 49, # 25 p. 7540 - 7544
反应条件
1: thionyl chloride
View Scheme
参考文献
Marsh; Stephen
Journal of the Chemical Society, 1925 , vol. 127, p. 1635
反应条件
trichloroethane, 1,1,1-; potassium carbonate
参考文献
Di Paco; Tauro
Farmaco, Edizione Scientifica, 1958 , vol. 13, p. 64,72, 73
参考文献
Sarbhai,K.P.; Mathur,K.B.L.
Indian Journal of Chemistry, 1966 , vol. 4, p. 81 - 85
参考文献
Sarbhai,K.P.; Mathur,K.B.L.
Indian Journal of Chemistry, 1966 , vol. 4, p. 81 - 85
