1,3-二氯-5,5-二甲基海因合成路线 （共 20 条）
反应条件
trichloroisocyanuric acid in acetonitrile T=20°C; 0.5 h;
参考文献
Tetrahedron Letters, , vol. 50, # 6 p. 656 - 658
反应条件
water anschliessend mit wss. NaOH und Chlor;
参考文献
Anales de la Asociacion Quimica Argentina (1921-2001), , vol. 41, p. 153
反应条件
1: hydrochloric acid 2: water; chlorine / 8 - 10 °C View Scheme
参考文献
Journal fuer Praktische Chemie (Leipzig), , vol. <2>113, p. 263 Anm.4
反应条件
tetrachloromethane; dibenzoyl peroxide
参考文献
Green et al.
Journal of the Chemical Society, 1959 , p. 3362,3369
参考文献
Petterson; Grzeskowiak
Journal of Organic Chemistry, 1959 , vol. 24, p. 1414,1418
反应条件
1: isoquinoline With sulfuric acid T=2 - 21°C; 0.25 h; 2: 1,3-Dichloro-5,5-dimethyl-2,4-imidazolidinedione T=10 - 55°C; 18.5 h; regioselective reaction;
参考文献
Walker, Matthew D.; Andrews, Benjamin I.; Burton, Andrew J.; Humphreys, Luke D.; Kelly, Gary; Schilling, Mark B.; Scott, Peter W.
Organic Process Research and Development, 2010 , vol. 14, # 1 p. 108 - 113
参考文献
Orazi et al.
Anales de la Asociacion Quimica Argentina (1921-2001), 1952 , vol. 40, p. 61,71
反应条件
sodium hydroxide; bromine; sodium carbonate
参考文献
Drug Research Inc.
Patent: US2868787 , 1956 ;
参考文献
Orazi et al.
Anales de la Asociacion Quimica Argentina (1921-2001), 1952 , vol. 40, p. 61,71
参考文献
Anales de la Asociacion Quimica Argentina (1921-2001), , vol. 40, p. 61,71
