反应条件
1: 2,6-dichlorotoluene With 2,2,6,6-tetramethyl-piperidine; n-butyllithium in tetrahydrofuran
T=-78°C; Inert atmosphere;
2: carbon dioxide in tetrahydrofuran
T=20°C; 4 h;
参考文献
GLAXO GROUP LIMITED; DEAN, David Kenneth; MUNOZ-MURIEDAS, Jorge; SIME, Mairi; STEADMAN, Jon Graham Anthony; THEWLIS, Rachel Elizabeth Anne; TRANI, Giancarlo; WALTER, Daryl Simon
Patent: WO2010/125102 A1, 2010 ;
Location in patent: Page/Page column 100 ;
WO 2010/125102 A1