反应条件
1: 1.) sodium ethoxide, 2.) copper / 1.) ethanol, 2.) 190 deg C, 3 h 2: thionyl chloride / 2 h / 100 °C 3: diethyl ether / Ambient temperature 4: AgNO3, NH4OH / dioxane; H2O / 16 h / Heating 5: aq. NaOH / 2-ethoxy-ethanol / 16 h / Heating View Scheme
参考文献
Atkinson, David C.; Godfrey, Keith E.; Meek, Bernard; Saville, John F.; Stillings, Michael R.
Journal of Medicinal Chemistry, 1983 , vol. 26, # 10 p. 1353 - 1360