4-氯-3,5-二硝基苯甲酸合成路线 （共 31 条）
反应条件
(i) (esterification), (ii) /BRN= 1839368/; Multistep reaction;
参考文献
Crampton,M.R.; Khan,H.A.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1972 , p. 1173 - 1177
参考文献
Evans; Reith
Biochemical Journal, 1954 , vol. 56, p. 111,114
反应条件
1: sodium acetate; aqueous ethanol 2: SnCl2; concentrated aqueous HCl / Erhitzen des Reaktionsgemisches mit wss. HCl View Scheme
参考文献
Albert; Duewell
Journal of the Society of Chemical Industry, London, 1947 , vol. 66, p. 11
参考文献
Barnes et al.
Journal of the Chemical Society, 1953 , p. 764,771
反应条件
sodium hydroxide in water; acetonitrile
T=25°C; in the presence of cetyltrimethylammonium chloride; other surfactants; var. conc. of NaOH; Rate constant;
参考文献
Broxton, Trevor J.; Marcou, Victor
Journal of Organic Chemistry, 1991 , vol. 56, # 3 p. 1041 - 1044
反应条件
1: sodium acetate; aqueous ethanol
2: SnCl2; concentrated aqueous HCl / Erhitzen des Reaktionsgemisches mit wss. HCl
View Scheme
参考文献
Albert; Duewell
Journal of the Society of Chemical Industry, London, 1947 , vol. 66, p. 11
反应条件
ammonium hydroxide in methanol
3 h; Heating;
参考文献
Elkin; Tolkacheva; Chernysheva; Karmanova; Konyushkin; Semenov
Russian Chemical Bulletin, 2007 , vol. 56, # 6 p. 1216 - 1226
反应条件
potassium hydroxide
T=0 - 20°C; 2.5 h; Heating / reflux;
参考文献
GLAXO GROUP LIMITED
Patent: WO2004/50619 A1, 2004 ;
Location in patent: Page 24-25 ;
WO 2004/050619 A1
参考文献
Ullmann
Justus Liebigs Annalen der Chemie, 1909 , vol. 366, p. 89
反应条件
1: 99.2 percent / conc. H2SO4 / 1.) 4 h, reflux, 2.) 25 deg C, 12-15 h
2: 84.6 percent / copper powder / xylene / Heating; 1.) 2 h, 2.) 1 h
3: 85 percent / 1.) 96percent H2SO4, 2.) H2O / 1.) 70 deg C, 2.) 95 deg C, 1h
4: 1.) oleum (20percent SO3), 2.) sodium azide
5: 23.4 percent / HNO3, H2SO4 / 1.) 30-35 deg C, 1.5 h, 2.) 65 deg C, 30 min, 3.) 70 deg C, 1.5 h
6: 38.6 percent / oleum (30percent SO3), H2O2 / 1.) 8-12 deg C, 1 h, 2.) 14 d, 25 deg C
View Scheme
参考文献
Nielsen, Arnold T.; Norris, William P.; Atkins, Ronald L.; Vuono, William R.
Journal of Organic Chemistry, 1983 , vol. 48, # 7 p. 1056 - 1059
