4,5,6,7-四氢吡唑并[1,5-a]吡啶-3-羧酸乙酯合成路线 （共 10 条）
反应条件
hydrogen; palladium on activated charcoal in ethanol T=80°C; P=12160 Torr; 5 h;
参考文献
Gmeiner; Schuenemann
Archiv der Pharmazie, 1988 , vol. 321, # 9 p. 517 - 520
参考文献
Wyeth
Patent: US2004/132708 A1, 2004 ;
反应条件
in o-xylene 16 h; Heating / reflux;
参考文献
Wyeth
Patent: US2006/276445 A1, 2006 ;
Location in patent: Page/Page column 19 ;
反应条件
in o-xylene 16 h; Heating;
参考文献
Xiong, Yifeng; Ullman, Brett; Choi, Jin-Sun Karoline; Cherrier, Martin; Strah-Pleynet, Sonja; Decaire, Marc; Feichtinger, Konrad; Frazer, John M.; Yoon, Woo H.; Whelan, Kevin; Sanabria, Erin K.; Grottick, Andrew J.; Al-Shamma, Hussien; Semple, Graeme
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 5 p. 1870 - 1873
反应条件
1.1: 55 percent / KOH / dimethylformamide / 28 h / 20 °C 2.1: (TMS)3SiH; Et3B; air / cyclohexane / 8 h / 20 °C 2.2: 36 percent / (TMS)3SiH; Et3B / 12 h View Scheme
参考文献
Lockner, Jonathan W.; Dixon, Darryl D.; Risgaard, Rune; Baran, Phil S.
Organic Letters, 2011 , vol. 13, # 20 p. 5628 - 5631
反应条件
1: 72 percent / K2CO3, air-O2 / tetrahydrofuran / 1.5 h / Ambient temperature 2: 90 percent / H2 / Pd/C / ethanol / 5 h / 80 °C / 12001 Torr View Scheme
参考文献
Loeber, Stefan; Huebner, Harald; Gmeiner, Peter
Bioorganic & Medicinal Chemistry Letters, 1999 , vol. 9, # 1 p. 97 - 102
反应条件
1: KHF2 / methanol; water / 0.25 h / 20 °C 2: dipotassium peroxodisulfate; silver nitrate / water; 2,3,4-trifluorotoluene / 1 h / 60 °C View Scheme
参考文献
Lockner, Jonathan W.; Dixon, Darryl D.; Risgaard, Rune; Baran, Phil S.
Organic Letters, 2011 , vol. 13, # 20 p. 5628 - 5631
反应条件
1: acetic acid; sodium nitrite 2: trifluoroacetic anhydride 3: anhydrous xylene / Reflux View Scheme
参考文献
Xiong, Yifeng; Ullman, Brett; Choi, Jin-Sun Karoline; Cherrier, Martin; Strah-Pleynet, Sonja; Decaire, Marc; Feichtinger, Konrad; Frazer, John M.; Yoon, Woo H.; Whelan, Kevin; Sanabria, Erin K.; Grottick, Andrew J.; Al-Shamma, Hussien; Semple, Graeme
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 5 p. 1870 - 1873
反应条件
ethanol; sodium hydroxide
参考文献
Xiong, Yifeng; Ullman, Brett; Choi, Jin-Sun Karoline; Cherrier, Martin; Strah-Pleynet, Sonja; Decaire, Marc; Feichtinger, Konrad; Frazer, John M.; Yoon, Woo H.; Whelan, Kevin; Sanabria, Erin K.; Grottick, Andrew J.; Al-Shamma, Hussien; Semple, Graeme
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 5 p. 1870 - 1873
反应条件
sodium methylate 1) 0 deg C, 1 h, 2) room temp., 12 h;
参考文献
Gmeiner; Sommer
Archiv der Pharmazie, 1990 , vol. 323, # 12 p. 991 - 993
