De(cladinosyl) Clarithromycin合成路线 （共 2 条）
反应条件
1: 82 percent / K2CO3 / acetone / 20 h / Ambient temperature 2: EDC*HCl, pyridinium trifluoroacetate, DMSO / CH2Cl2 / 4 h / Ambient temperature 3: 79 percent / pyridine / 5 h / Ambient temperature 4: 88 percent / DBU / acetone / 20 h / Ambient temperature 5: 1.) NaH / 1.) DMF, -10 deg C, 2.) DMF, -10 deg C, 1 h View Scheme
参考文献
Agouridas, Constantin; Denis, Alexis; Auger, Jean-Michel; Benedetti, Yannick; Bonnefoy, Alain; Bretin, Francois; Chantot, Jean-Francois; Dussarat, Arlette; Fromentin, Claude; D'Ambrieres, Solange Gouin; Lachaud, Sylvette; Laurin, Patrick; Martret, Odile Le; Loyau, Veronique; Tessot, Nicole
Journal of Medicinal Chemistry, 1998 , vol. 41, # 21 p. 4080 - 4100
反应条件
Multi-step reaction with 4 steps 1: 82 percent / K2CO3 / acetone / 20 h / Ambient temperature2: EDC*HCl, pyridinium trifluoroacetate, DMSO / CH2Cl2 / 4 h / Ambient temperature3: 79 percent / pyridine / 5 h / Ambient temperature4: 88 percent / DBU / acetone / 20 h / Ambient temperature
参考文献
Agouridas, Constantin; Denis, Alexis; Auger, Jean-Michel; Benedetti, Yannick; Bonnefoy, Alain; Bretin, Francois; Chantot, Jean-Francois; Dussarat, Arlette; Fromentin, Claude; D'Ambrieres, Solange Gouin; Lachaud, Sylvette; Laurin, Patrick; Martret, Odile Le; Loyau, Veronique; Tessot, Nicole Journal of Medicinal Chemistry, 1998 , vol. 41, # 21 p. 4080 - 4100
