tert.-butyl lithium in diethyl ether; toluene; pentane 1 h;

1: 45 percent / n-buthyl lithium / diethyl ether; hexane; tetrahydrofuran / 0.5 h / -70 °C 2: 1.) acetic acid, 2.) HBr / 1.) 100 deg C, 2.) 0.5 h 3: 98 percent / t-butyl lithium / toluene; diethyl ether; pentane / 1 h View Scheme

1: 45 percent / n-buthyl lithium / diethyl ether; hexane; tetrahydrofuran / 0.5 h / -70 °C 2: 1.) acetic acid, 2.) HBr / 1.) 100 deg C, 2.) 0.5 h 3: 98 percent / t-butyl lithium / toluene; diethyl ether; pentane / 1 h View Scheme