potassium carbonate in N,N-dimethyl-formamide T=80°C; 6.5 h;

potassium carbonate in N,N-dimethyl-formamide T=100°C; 16 h; Yield given;

1: 99 percent / dimethylformamide / 20 h / Ambient temperature 2: 79 percent / H2 / 10percent Pd/C / acetic acid / 17 h / 40 °C 3: 71 percent / NaH / dimethylformamide / 1 h / 0 - 5 °C 4: 80 percent / conc. HCl / methanol / 1 h / Heating 5: 78 percent / Zn, NH4Cl / methanol / 0.67 h 6: 67 percent / K2CO3 / dimethylformamide / 6.5 h / 80 °C View Scheme

1: 80 percent / conc. HCl / methanol / 1 h / Heating 2: 78 percent / Zn, NH4Cl / methanol / 0.67 h 3: 67 percent / K2CO3 / dimethylformamide / 6.5 h / 80 °C View Scheme