1: sodium hydroxide / methanol / 1 h 2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.5 h / 0 - 20 °C 3: tri-isopropoxy-borane; n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C 4: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; triethylamine / water; ethylene glycol dimethyl ether / 4 h / 90 °C 5: hydrogenchloride / 1,4-dioxane / 20 °C 6: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C View Scheme