反应条件
1.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 °C
1.2: 4 h / 0 - 50 °C
2.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / -78 - 20 °C
2.2: 1 h / 20 °C
3.1: 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogenphosphate / water; tert-butyl alcohol / 0.5 h / 20 °C
3.2: pH 1
View Scheme
参考文献
Clark, Roger B.; He, Minsheng; Deng, Yonghong; Sun, Cuixiang; Chen, Chi-Li; Hunt, Diana K.; O'Brien, William J.; Fyfe, Corey; Grossman, Trudy H.; Sutcliffe, Joyce A.; Achorn, Catherine; Hogan, Philip C.; Katz, Christopher E.; Niu, John; Zhang, Wu-Yan; Zhu, Zhijian; Ronn, Magnus; Xiao, Xiao-Yi
Journal of Medicinal Chemistry, 2013 , vol. 56, # 20 p. 8112 - 8138