1-Boc-哌啶-3-甲醛合成路线 （共 15 条）
反应条件
1: With oxalyl dichloride; dimethyl sulfoxide in dichloromethane T=-78 - 68°C; 0.5 h; 2: With triethylamine in dichloromethane T=20°C; 16 h;
参考文献
ASTRAZENECA AB
Patent: WO2006/62465 A1, 2006 ;
Location in patent: Page/Page column 40 ;
WO 2006/062465 A1
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=-15°C; 0.5 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 15 p. 4013 - 4017
反应条件
molecular sieves in tetrahydrofuran; dichloromethane
参考文献
Bridger, Gary; Kaller, Al; Harwig, Curtis; Skerlj, Renato; Bogucki, David; Wilson, Trevor R.; Crawford, Jason; McEachern, Ernest J.; Atsma, Bem; Nan, Siqiao; Zhou, Yuanxi; Schols, Dominique; Smith, Christopher D.; Di Fluri, Maria R.
Patent: US2004/19058 A1, 2004 ;
US 20040019058 A1
反应条件
anhydrous sodium hydrogen carbonate; sodium chloride; dimethyl sulfoxide; triethylamine in dichloromethane; water
反应条件
silica gel in dichloromethane
参考文献
US6331545 B1, ;
US 6331545 B1
反应条件
1: 88 percent / aq. NaOH / dioxane / 12 h / 20 °C 2: 100 percent / PyBOP; Et3N / CH2Cl2 / 12 h / 20 °C 3: LiAlH4 / tetrahydrofuran / 0.5 h / -15 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 15 p. 4013 - 4017
反应条件
1: 100 percent / PyBOP; Et3N / CH2Cl2 / 12 h / 20 °C 2: LiAlH4 / tetrahydrofuran / 0.5 h / -15 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 15 p. 4013 - 4017
反应条件
1: 88 percent / aq. NaOH / dioxane / 12 h / 20 °C 2: 100 percent / PyBOP; Et3N / CH2Cl2 / 12 h / 20 °C 3: LiAlH4 / tetrahydrofuran / 0.5 h / -15 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 15 p. 4013 - 4017
反应条件
1: CH2Cl2 / 1 h / 20 °C 2: tetrapropylammoniumperruthenate; NMO; 3 Angstroem molecular sieves / CH2Cl2 / 1 h View Scheme
参考文献
Bioorganic and medicinal chemistry letters, , vol. 12, # 13 p. 1785 - 1789
反应条件
1: sodium triacetoxyborohydride; acetic acid / CH2Cl2 / 16 h / 20 °C 2: hydrochloric acid / ethyl acetate / 1 h View Scheme
参考文献
Peschke, Bernd; Bak, Sonja; Hohlweg, Rolf; Pettersson, Ingrid; Frolund Refsgaard, Hanne Hoffmann; Viuff, Dorthe; Rimvall, Karin
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 10 p. 2603 - 2616
