1-Boc-哌啶-3-甲醛合成路线 （共 15 条）
反应条件
sodium hydroxide in 1,4-dioxane; hexane
参考文献
Bayer Aktiengesellschaft
Patent: US6562811 B1, 2003 ;
反应条件
potassium carbonate in methanol T=20°C; 3 h;
参考文献
Bourrain, Sylvie; Hunt, Peter Alan; Huscroft, Ian Thomas; Kulagowski, Janusz Jozef; London, Clare; Naylor, Elizabeth Mary; Raubo, Piotr Antoni; Seward, Eileen Mary
Patent: US2004/229864 A1, 2004 ;
Location in patent: Page/Page column 11 ;
US 20040229864 A1
反应条件
potassium carbonate in methanol 2.16667 h; Cooling with ice;
参考文献
Astar Biotech LLC; YU, Chunrong; Huang, Haihong; Zhang, Dongfeng; Li, Peng
Patent: US2014/31354 A1, 2014 ;
Location in patent: Paragraph 0296; 0421; 0422 ;
反应条件
1: Methyltriphenylphosphonium bromide With potassium hexamethylsilazane in tetrahydrofuran; toluene T=0°C; 0.5 h; 2: 3-Formyl-piperidine-1-carboxylic acid tert-butyl ester in tetrahydrofuran; toluene T=0 - 20°C; 3 h;
参考文献
GLAXO GROUP LIMITED; ATKINSON, Francis Louis; ATKINSON, Stephen John; BARKER, Michael David; DOUAULT, Clement; GARTON, Neil Stuart; LIDDLE, John; PATEL, Vipulkumar Kantibhai; PRESTON, Alexander G; SHIPLEY, Tracy Jane; WILSON, David Matthew; WATSON, Robert J
Patent: WO2012/123312 A1, 2012 ;
Location in patent: Page/Page column 78-79 ;
WO 2012/123312 A1
反应条件
1: With ammonium acetate in 1,4-dioxane
T=90°C;
2: With chloranil in 1,4-dioxane; ethyl acetate
T=20°C; 1.5 h;
3: With ascorbic acid powder in 1,4-dioxane; ethyl acetate
T=20°C; 1.5 h;
参考文献
BAYER AKTIENGESELLSCHAFT
Patent: WO2003/76447 A1, 2003 ;
Location in patent: Page/Page column 28 ;
