5-氨基-2,4-二叔丁基苯甲酸甲酯合成路线 （共 5 条）
反应条件
hydrogen; 5 Pd(II)/C(eggshell) in methanol T=25°C; P=1500.15 Torr; Inert atmosphere;
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
1: triethylamine / diethyl ether / 0 - 20 °C 2: nitric acid; sulfuric acid / 1 h / 0 - 20 °C 3: hydrogen / 5 palladium on charcoal / methanol / 20 - 30 °C / 1500.15 Torr / Inert atmosphere View Scheme
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
1: nitric acid; sulfuric acid / 1 h / 0 - 20 °C 2: hydrogen / 5 palladium on charcoal / methanol / 20 - 30 °C / 1500.15 Torr / Inert atmosphere View Scheme
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
1: With pyridine; 1-propanephosphonic acid cyclic anhydride in 2-methyl tetrahydrofuran T=47.5°C; 8 h; 2: With methanol; sodium methylate in 2-methyl tetrahydrofuran Temperature;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED; VERWIJS, Marinus, Jacobus; KARKARE, Radhika; MOORE, Michael, Douglas
Patent: WO2014/71122 A1, 2014 ;
反应条件
pyridine; hydrogenchloride; sodium methylate in methanol; water; acetonitrile
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
