(R)-1-(苄基氨基)-4-甲基-1-氧代-2-戊基氨基甲酸叔丁酯合成路线 （共 7 条）
反应条件
N-ethyl-N,N-diisopropylamine; HATU in N,N-dimethyl-formamide
T=0 - 20°C; 2.5 h;
参考文献
MEDIVIR AB
Patent: WO2008/107365 A1, 2008 ;
Location in patent: Page/Page column 63 ;
WO 2008/107365 A1
反应条件
1: N-methylmorpholine / CH2Cl2 / 0.5 h / -15 °C
2: CH2Cl2 / 15 h / 4 °C
View Scheme
参考文献
Girodano; Gallina; Ottaviano; Consalvi; Scandurra
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 9 p. 865 - 873
反应条件
4-(trifluoromethyl)phenol; sodium methylate in toluene
T=70°C; 99 h; Inert atmosphereMolecular sieve; optical yield given as percent ee;
参考文献
Ohshima, Takashi; Hayashi, Yukiko; Agura, Kazushi; Fujii, Yuka; Yoshiyama, Asako; Mashima, Kazushi
Chemical Communications, 2012 , vol. 48, # 44 p. 5434 - 5436
反应条件
triethylamine in dichloromethane
参考文献
Postnikova, Brenda J.; Anslyn, Eric V.
Tetrahedron Letters, 2004 , vol. 45, # 3 p. 501 - 504
反应条件
T=40°C; in incubator;
参考文献
Nadimpally, Krishna Chaitanya; Thalluri, Kishore; Palakurthy, Nani Babu; Saha, Abhijit; Mandal, Bhubaneswar
Tetrahedron Letters, 2011 , vol. 52, # 20 p. 2579 - 2582
反应条件
triethylamine in ethylene glycol dimethyl ether
18 h; Ambient temperature;
参考文献
DeSolms; Giuliani; Guare; Vacca; Sanders; Graham; Wiggins; Darke; Sigal; Zugay; Emini; Schleif; Quintero; Anderson; Huff
Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2852 - 2857
反应条件
in dichloromethane
T=4°C; 15 h; Yield given;
参考文献
Girodano; Gallina; Ottaviano; Consalvi; Scandurra
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 9 p. 865 - 873
