6-氯-5-(2-氯乙基)羟吲哚合成路线 （共 20 条）
反应条件
1: AlCl3, aluminium chloride / dichloromethane / 20 h / |Reflux; |Inert atmosphere 2: AlCl3, aluminium chloride; 1,1,3,3-tetramethyldisiloxane / dichloromethane / 0 °C / |Inert atmosphere View Scheme
参考文献
Organic Process Research and Development, , vol. 12, # 6 p. 1142 - 1145
反应条件
1: AlCl3, aluminium chloride / dichloromethane / 20 h / |Reflux; |Inert atmosphere 2: AlCl3, aluminium chloride; triethylsilane / dichloromethane / 12 h / 0 - 20 °C / |Inert atmosphere; |Reflux View Scheme
参考文献
Organic Process Research and Development, , vol. 12, # 6 p. 1142 - 1145
反应条件
sodium carbonate in 1-methyl-pyrrolidin-2-one T=130 - 135°C; 24 h; Product distribution / selectivity;
参考文献
APOTEX PHARMACHEM INC.
Patent: WO2006/47893 A1, 2006 ;
Location in patent: Page/Page column 7 ;
反应条件
in water Inert atmosphereRefluxdispersing agent;
参考文献
ALKEM LABORATORIES LIMITED
Patent: US2011/3995 A1, 2011 ;
Location in patent: Page/Page column 5 ;
反应条件
Morwet D425 in water RefluxInert atmosphere; Product distribution / selectivity;
参考文献
ALKEM LABORATORIES LIMITED
Patent: US2011/3995 A1, 2011 ;
Location in patent: Page/Page column 5 ;
反应条件
tetrabutylammomium bromide; sodium carbonate; sodium iodide in cyclohexane Heating / reflux;
参考文献
Venkataraman, Sundaram; Rao, Uppala Venkata Bhaskara; Muvva, Venkateswarlu; Chitta, Vijayawardhan
Patent: US2006/89502 A1, 2006 ;
Location in patent: Page/Page column 7 ;
反应条件
sodium carbonate in 1-methyl-pyrrolidin-2-one T=130 - 135°C; 24 h; Product distribution / selectivity;
参考文献
APOTEX PHARMACHEM INC.
Patent: WO2006/47893 A1, 2006 ;
Location in patent: Page/Page column 7 ;
反应条件
in water Inert atmosphereRefluxdispersing agent;
参考文献
ALKEM LABORATORIES LIMITED
Patent: US2011/3995 A1, 2011 ;
Location in patent: Page/Page column 5 ;
反应条件
Morwet D425 in water RefluxInert atmosphere; Product distribution / selectivity;
参考文献
ALKEM LABORATORIES LIMITED
Patent: US2011/3995 A1, 2011 ;
Location in patent: Page/Page column 5 ;
反应条件
tetrabutylammomium bromide; sodium carbonate; sodium iodide in cyclohexane Heating / reflux;
参考文献
Venkataraman, Sundaram; Rao, Uppala Venkata Bhaskara; Muvva, Venkateswarlu; Chitta, Vijayawardhan
Patent: US2006/89502 A1, 2006 ;
Location in patent: Page/Page column 7 ;
