5-氯乙酰-6-氯-1,3-二氢-2H-吲哚-2-酮合成路线 （共 12 条）
反应条件
aluminium trichloride in carbon disulfide
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 1 p. 143 - 148
反应条件
1: 6-chloro-1,3-dihydro-2H-indol-2-one With AlCl3, aluminium chloride in dichloromethane T=4 - 26°C; 0.5 h; 2: chloroacetyl chloride in dichloromethane 9 h; Heating / reflux; 3: With hydrogenchloride; water in dichloromethane T=0°C; 0.75 h;
参考文献
US2005/49295 A1, ;
Page 5 ;
反应条件
1.1: potassium carbonate / dimethyl sulfoxide / 25 - 30 °C / Inert atmosphere 1.2: 16 h / 40 - 85 °C 2.1: hydrogenchloride; tin / water; methanol / 10 - 70 °C 3.1: AlCl3, aluminium chloride / 1,2-dichloro-ethane / 20 °C / Inert atmosphere 3.2: 35 - 37 °C / Inert atmosphere View Scheme
反应条件
1.1: hydrogenchloride; tin / water; methanol / 10 - 70 °C 2.1: AlCl3, aluminium chloride / 1,2-dichloro-ethane / 20 °C / Inert atmosphere 2.2: 35 - 37 °C / Inert atmosphere View Scheme
反应条件
tetrabutylammomium bromide; sodium carbonate; sodium iodide in cyclohexane Heating / reflux;
参考文献
Venkataraman, Sundaram; Rao, Uppala Venkata Bhaskara; Muvva, Venkateswarlu; Chitta, Vijayawardhan
Patent: US2006/89502 A1, 2006 ;
Location in patent: Page/Page column 7 ;
反应条件
1: Et3SiH, CF3COOH 2: Na2CO3, NaI / 3-methyl-butan-1-ol / 72 h / Heating View Scheme
参考文献
ARCH PHARMALABS LIMITED; GHOGARE, Bhausaheb Nana; DESHPANDE, Uday K.; PAI, Ganesh Gurpur; MANDAL, Arun Kanti; CHARANJIT, Sehgal; NEHA, Dixit Akshaya
Patent: WO2012/20424 A1, 2012 ;
反应条件
triethylsilane; trifluoroacetic acid
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 1 p. 143 - 148
反应条件
triethylsilane; trifluoroacetic acid 7 h;
参考文献
US2006/89502 A1, ;
Page/Page column 7 ;
反应条件
AlCl3, aluminium chloride; dimethylmono-chlorosilane in dichloromethane T=0°C; Inert atmosphere; chemoselective reaction;
参考文献
Organic Process Research and Development, , vol. 12, # 6 p. 1142 - 1145
反应条件
triethylsilane; AlCl3, aluminium chloride in dichloromethane T=0 - 20°C; 12 h; Inert atmosphereReflux;
参考文献
Organic Process Research and Development, , vol. 12, # 6 p. 1142 - 1145
