(S)-1-苄基-3-甲烷氧基吡咯烷合成路线 （共 14 条）
参考文献
Hoffmann-La Roche Inc.
Patent: US5977381 A1, 1999 ;
反应条件
1: NaN3 / dimethylformamide / 80 °C 2: LiAlH4 / tetrahydrofuran / 6 h / Heating 3: CH2Cl2 / 20 °C View Scheme
参考文献
Huang; Luedtke; Freeman; Wu; Mach
Journal of Medicinal Chemistry, 2001 , vol. 44, # 11 p. 1815 - 1826
反应条件
1: dimethylsulfoxide / 0.83 h / 120 °C 2: 77 percent / aq. NaOH / methanol / Ambient temperature View Scheme
参考文献
Bioscience, Biotechnology and Biochemistry, , vol. 59, # 7 p. 1287 - 1290
反应条件
sodium hydroxide; sodium acetate 1.) DMSO, 120 deg C, 50 min, 2.) MeOH, 25 deg C, 1 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Bioscience, Biotechnology and Biochemistry, , vol. 59, # 7 p. 1287 - 1290
反应条件
sodium hydroxide; sodium acetate 1.) DMSO, 120 deg C, 50 min, 2.) MeOH, 25 deg C, 1 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Horiguchi; Mochida
Bioscience, Biotechnology and Biochemistry, 1995 , vol. 59, # 7 p. 1287 - 1290
反应条件
in acetonitrile T=65°C; 6 h;
参考文献
Fedij, Victor; Lenoir, Edward A.; Suto, Mark J.; Zeller, James R.; Wemple, James
Tetrahedron: Asymmetry, 1994 , vol. 5, # 7 p. 1131 - 1134
反应条件
cyanure de tetrabutylammonium in acetonitrile 48 h; Heating / reflux;
参考文献
WARNER-LAMBERT COMPANY LLC
Patent: WO2005/49605 A1, 2005 ;
Location in patent: Page/Page column 115; 116; 148 ;
参考文献
Hoffmann-La Roche Inc.
Patent: US5977381 A1, 1999 ;
反应条件
triethylamine in toluene
T=0 - 20°C; 3.91667 h;
参考文献
ACHILLION PHARMACEUTICALS, INC.
Patent: WO2007/14308 A1, 2007 ;
Location in patent: Page/Page column 70 ;
反应条件
potassium carbonate; potassium iodide in tetrahydrofuran; water
7.5 h; Heating / reflux;
参考文献
PPG-SIPSY, a corporation of France
Patent: US2004/34235 A1, 2004 ;
Location in patent: Page 3 ;
